The GSI heavy ion microbeam
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A Laser Microbeam Implemented at the Heavy-Ion Microbeam Facility
The heavy-ion microbeam is used for targeted irradiation of living cells (in culture) with ions from the UNILAC linear accelerator of GSI [1]. A custom-made epifluorescence microscope is available for beam targeting as well as for observation of proteins (tagged by fluorescent dyes) in sub-compartments of interest. In order to gain better insight into DNA damage repair processes, we intend to e...
متن کاملFirst Sub-Micron Targeting with Single Ions
Since 2003, we use the GSI heavy-ion microprobe to irradiate living cells with ions from the UNILAC [1]. Two specific properties of the microbeam method make it stand out among other, more conventional irradiation procedures: First, we precisely control the dose by counting and switching individual particles that are to be delivered to the target, down to the low-dose limit of a single ion per ...
متن کاملContrast enhancement for in-situ GFP microscopy at the microbeam
In collaboration with GSI Biophysics, the microbeam, operated with ions from the UNILAC linear accelerator of GSI, is routinely employed for targeted irradiation of living cells in culture [1]. A custom-made fluorescence microscope is used both for beam targeting and for cell observation via fluorescent dyes that specifically highlight the biological agent of interest. Green Fluorescent Protein...
متن کاملUse of Microbeam at Jaea Takasaki
The TIARA facilities of JAEA in Takasaki is equipped with a several-MeV light-ion and a several-dozen-MeV heavy-ion microbeam formation systems of focusing type, and a several-hundred-MeV heavy-ion microbeam formation system of collimating type. The microbeams with a spot size of 1 μm or less in diameter are extensively utilized for the research in materials science and biotechnology. An in-air...
متن کاملA performance study of the conceptual implementation of the GEM-tracking detector in Monte Carlo simulation
PANDA experiment (antiProton ANnihilation at DArmstadt) is one of the key projects of the future FAIR facilities to investigate the reactions of antiprotons with protons and nuclear targets. experiment is designed to serve as a completely extraordinary physical potential due to exploiting the availability of cold and high-intensity beams of antiprotons. One of the significant parts of the ...
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